Retinol—a derivative of vitamin A that boasts a long list of proven benefits—has been called the holy grail of skincare ingredients. With results that include improved skin texture, boosted collagen production and diminished dark spots, it’s easy to see why beauty lovers all over the world swear by the powerhouse active. But retinol use also comes with its fair share of side effects, like irritation and redness.

We asked Julia Carroll, a dermatologist at Toronto-based Compass Dermatology, and Amanda Mizen, a medical aesthetician and owner of Toronto-based North Medical Spa, for advice on how to incorporate retinol into your skincare routine.